Arsenic: Association of regional concentrations in drinking water with suicide and natural causes of death in Italy (2025)

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Suicide behaviour and arsenic levels in drinking water: a possible association?: A review of the literature about the effects of arsenic contamination in drinking water on suicides

Paola Melai

Egyptian journal of forensic sciences, 2017

A considerable part of the global population is exposed to arsenic-contaminated drinking water which is the main source of inorganic arsenic(As) exposure in humans. Arsenic exposure interferes with the action of enzymes, essential cations, and transcriptional events in cells throughout the body, and a multitude of multisystemic non-cancer effects might ensue. The aim of our review was to evaluate the effects of arsenic contamination in drinking water on suicides rates. A systematic literature search (English written literature) was conducted in electronic databases MEDLINE, SCOPUS. Evidences dating from 1999 till 2016 have been collected. A manual search of reference lists of included studies and review articles was successively performed. All references of the retrieved studies were also reviewed to avoid missing relevant publications. The key search terms included: "arsenic AND water AND suicide". The literature search yielded 13 publications, but we identified 2 manuscr...

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Epidemiological and Spatial Association between Arsenic Exposure via Drinking Water and Morbidity and Mortality

Md. Sohel Parvez

2010

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Arsenic in Drinking Water and Adult Mortality

Epidemiology, 2009

Background: Arsenic is a potent human carcinogen and toxicant. Elevated concentration of arsenic in drinking water is a major public-health problem worldwide. We evaluated risks of adult mortality (due to cancer and cardiovascular and infectious diseases) in relation to arsenic exposure through drinking water. Methods: A cohort analysis was applied to survival data prospectively collected during 1991-2000 in a health and demographic surveillance system in Matlab, Bangladesh, where tubewells were installed beginning in the early 1970s. A total of 115,903 persons aged 15 or more years on 1 January 1991 were available for analysis. In this period, 9015 people died and 22,488 were lost to follow-up. Arsenic exposure data were derived from a survey in 2002-2003 of past and current water use and arsenic concentrations in all tubewells. We estimated risk of excess mortality in relation to arsenic exposure, using proportional hazards models. Results: Even at low levels (10-49 g/L) of arsenic in drinking water, we observed increased risk of death due to all nonaccidental causes (hazard ratio ϭ 1.16 ͓95% confidence interval ϭ 1.06-1.26͔). Increased risks at exposure of 50-149 g/L were observed for death due to cancers (1.44 ͓1.06-1.95͔), cardiovascular disease (1.16 ͓0.96-1.40͔), and infectious diseases (1.30 ͓1.13-1.49͔). We observed clear dose-response relationships for each of these causes. Conclusions: Arsenic exposure through drinking water has generated excess adult mortality after 20-30 years of exposure.

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Urinary Arsenic in Human Samples from Areas Characterized by Natural or Anthropogenic Pollution in Italy

elisa bustaffa

International journal of environmental research and public health, 2018

Arsenic is ubiquitous and has a potentially adverse impact on human health. We compared the distribution of concentrations of urinary inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian areas with other international studies, and we assessed the relationship between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human biomonitoring study on 271 subjects (132 men) aged 20-44, randomly sampled and stratified by area, gender, and age. Data on environmental and occupational exposure and dietary habits were collected through a questionnaire. Arsenic was speciated using chromatographic separation and inductively coupled mass spectrometry. Associations between uc(iAs+MMA+DMA) and exposure factors were evaluated using the geometric mean ratio (GMR) with a 90% confidence interval by stepwise multiple regression analysis. The 95th percentile value of uc(iAs+MMA+DMA) for the whole sample (86.28 µg/L) was higher than other national studies worldwide. A statis...

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Arsenic in public water supplies and cardiovascular mortality in Spain

Jose Barrio

Environmental Research, 2010

Background: High-chronic arsenic exposure in drinking water is associated with increased cardiovascular disease risk. At low-chronic levels, as those present in Spain, evidence is scarce. In this ecological study, we evaluated the association of municipal drinking water arsenic concentrations during the period 1998 À 2002 with cardiovascular mortality in the population of Spain. Methods: Arsenic concentrations in drinking water were available for 1721 municipalities, covering 24.8 million people. Standardized mortality ratios (SMRs) for cardiovascular (361,750 deaths), coronary (113,000 deaths), and cerebrovascular (103,590 deaths) disease were analyzed for the period 1999 À 2003. Two-level hierarchical Poisson models were used to evaluate the association of municipal drinking water arsenic concentrations with mortality adjusting for social determinants, cardiovascular risk factors, diet, and water characteristics at municipal or provincial level in 651 municipalities (200,376 cardiovascular deaths) with complete covariate information.

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Mortality associated with arsenic in drinking water

Shivangi Bharti

Your file Votre reference ISBN: 978-0-494-44116-9 Our file Notre reference ISBN: 978-0-494-44116-9 NOTICE: The author has granted a nonexclusive license allowing Library and Archives Canada to reproduce, publish, archive, preserve, conserve, communicate to the public by telecommunication or on the Internet, loan, distribute and sell theses worldwide, for commercial or noncommercial purposes, in microform, paper, electronic and/or any other formats. AVIS: L'auteur a accorde une licence non exclusive permettant a la Bibliotheque et Archives Canada de reproduire, publier, archiver, sauvegarder, conserver, transmettre au public par telecommunication ou par Plntemet, prefer, distribuer et vendre des theses partout dans le monde, a des fins commerciales ou autres, sur support microforme, papier, electronique et/ou autres formats. Canada Bien que ces formulaires aient inclus dans la pagination, il n'y aura aucun contenu manquant.

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Lifetime exposure to arsenic in residential drinking water in Central Europe

Rupert Hough, Patrizia Gnagnarella, Giovanni Leonardi

…, 2008

Objective Methods and results are presented for an arsenic exposure assessment integral to an epidemiological case-control study of arsenic and cancer-the European Commission funded ASHRAM (Arsenic Health Risk Assessment and Molecular Epidemiology) study carried out in some counties of Hungary, Romania and Slovakia. Methods The exposure history of each participant (N = 1,392) was constructed by taking into account how much water they consumed (as water, in drinks and in food), sources of drinking water in their various residences over their lifetime, and the concentrations of arsenic in their various water supplies measured by Hydride Generation-Atomic Absorption Spectrometry (HG-AAS). Concentrations of arsenic in previous water supplies were either derived from contemporary analyses of the same source, or

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Arsenic in Drinking Water and Mortality for Cancer and Chronic Diseases in Central Italy, 1990-2010

Matteo Scortichini

PLOS ONE, 2015

Background In several volcanic areas of Italy, arsenic levels exceed European regulatory limits (10 μg/L in drinking water). There is still uncertainty about health risks from arsenic at low-medium doses (<100 μg/L). Objectives A large population-based study using an administrative cohort of residents in the Viterbo province (Central Italy), chronically exposed to low-medium arsenic levels via drinking water, was investigated to evaluate the effects of a lifetime exposure to arsenic on mortality from cancers and chronic diseases. Methods The study population consisted of 165,609 residents of 17 municipalities, followed from 1990 until 2010. Average individual arsenic exposure at the first residence (As I) was estimated through a space-time modeling approach using residential history and arsenic concentrations from water supply. A time-dependent Cumulative Arsenic dose Indicator (CAI) was calculated, accounting for daily water intake and exposure duration. Mortality Hazard Ratios (HR) were estimated by gender for different diseases using Cox proportional models, adjusting for individual and area-level confounders. A flexible non-parametric approach was used to investigate dose-response relationships. Results Mean As I exposure was 19.3 μg/L, and average exposure duration was 39.5 years. Associations of As I and CAI indicators with several diseases were found, with greatest risks found for lung cancer in both sexes (HR = 2.61 males; HR = 2.09 females), myocardial infarction, peripheral arterial disease and COPD in males (HR = 2.94; HR = 2.44; HR = 2.54 respectively) and diabetes in females (HR = 2.56). For lung cancer and cardiovascular diseases PLOS ONE |

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Low level arsenic contaminated water consumption and birth outcomes in Romania—An exploratory study

Edward Fitzgerald

Reproductive Toxicology, 2016

Women are exposed to drinking water with low arsenic concentrations (<10.0 μg/L) worldwide, yet little work has been done to assess the risk. To begin to address this data gap, we conducted an exploratory study of birth outcomes in Timis County, Romania. We prospectively followed 122 women with singleton deliveries, for whom we constructed individual exposure indicators using self-reported water consumption weighted by arsenic measured in drinking water sources. There were no overall confounder-adjusted effects for arsenic exposure on birth outcomes. Yet, higher average arsenic (10 μg/L) was associated with a −2.45 lower birth weight Z-score (P=0.021) and a −1.17 shorter birth length Z-score (P=0.029) among smokers. Higher average iAs (10 μg/L) was also associated with smaller ponderal index in boys (P=0.023). Our results suggest smoking may potentiate an otherwise benign arsenic exposure. A larger, more definitive biomarker-based study is needed to investigate the potential risks in conjunction with smoking.

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Statistical Analysis of Causes of Death (2005–2010) in Villages of Simav Plain, Turkey, With High Arsenic Levels in Drinking Water Supplies

Orhan Gündüz

Archives of Environmental &amp; Occupational Health, 2014

The purpose of this research was to compare the causes of death in 5 villages situated in Simav Plain, Turkey, during 2005-2010 where different arsenic levels were detected in drinking water supplies. Since groundwater in Simav Plain had arsenic concentrations that ranged between 7.1 and 833.9 ppb, a two-phase research was formulated. In the first phase, public health surveys were conducted with 1,003 villagers to determine the distribution of diseases. In the second phase, verbal autopsy surveys and official death records were used to investigate the causes of death. In total, 402 death cases were found in the study area where cardiovascular system diseases (44%) and cancers (15.2%) were major causes. Cancers of lung (44.3%), prostate (9.8%), colon (9.8%), and stomach (8.2%) were comparably higher in villages with high arsenic levels in drinking water supplies. Furthermore, the majority of cases of liver, bladder, and stomach cancers were observed in villages with high arsenic levels.

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Arsenic: Association of regional concentrations in drinking water with suicide and natural causes of death in Italy (2025)
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